Resources

Tech, Treatment, and Hope: What’s Coming and Why it Matters - The Diabetes Link

Written by Mary Taylor PharmD BCACP CDCES CPP | Dec 22, 2025, 5:00:00 AM

Introduction

Did you know that in ancient civilizations physicians would taste urine to diagnose diabetes? Seems weird, but sweet tasting urine meant you had diabetes. There weren’t any medication options available for treatment until 1921. Back then, your doctor would say, “hey, you’re going to have to stop eating carbs and try to incorporate herbal remedies to buy you some time… but unfortunately you’re simply not going to make it.”1-4 I think it is safe to say, diabetes management has truly came a LONG way. 

How did we go from 0 to 100 with diabetes care? You guessed it, RESEARCH! Research is needed to truly determine what is the issue going on and how to best resolve it. While our generation has come a long way with diabetes innovations, we still have a long way to go. We still need to understand:

  • What is happening in our bodies that causes different types of diabetes?
  • How can diabetes management be made easier? Technology? New medications? New resources? 
  • How can a cure for diabetes be possible?

We get closer to answering these questions by exploring different areas in research, moving the needle closer with each new effort in different areas of diabetes research:

Types of Diabetes Research

1. Diabetes Technology: Improve Current Diabetes Tech + Innovate New Tech

Diabetes technology is evolving fast! Insulin pumps, continuous glucose monitors (CGMs), continuous ketone monitors, smart insulin pens, manual glucometers that do not require a finger poke as well as manual glucometers that have smartphone app compatibility– these are all on the rise! As more options become available, there are more nuances to consider. It is unrealistic to expect we will eventually have the “perfect” device for ALL people living with diabetes because how each person manages their  diabetes is different! However, we can aim for a future where there are enough options available, so that there is something for every single person out there living with diabetes, to make diabetes management successful for all!

There are still populations that unfortunately take much longer to get medical devices approved for considering they are higher risk. For example, there are still no insulin pumps that are FDA approved for use in pregnancy! Crazy, right?!

Recent advancements have been exciting as there are more tubeless insulin pumps (vary in amount of insulin that can be used, how long the infusion set site can be worn and how environmentally friendly supplies are) and new insulin pump algorithms (imagine – living in a world where you don’t have to bolus before eating) on the way. Make sure you keep an eye out for information on these advancements: 

  • More Tubeless Pumps: right now, there’s only one option out there and that’s Omnipod. This fills up to 200 units max, uses a Teflon cannula, and can be worn up to 3 days. Other companies are exploring the possibilities of what else a tubeless pump can offer. 
    • Tandem’s Sigi offers a reusable pod with a charger (shout out for being environmentally friendly!). 
    • And Medtronic’s MiniMed Fit is exploring the possibility of a reusable pod that holds up to 300 units and could be worn for up to 7 days!  
    • Even BetaBionics is entering the tubeless game with Mint, offering different features like a smaller (4mm) steel cannula. 
  • New insulin pumps. For those on an intensive insulin regimen, hybrid closed loop systems are the gold standard of care according to the American Diabetes Association (when feasible and affordable to a patient.) A hybrid closed loop insulin pump utilizes an algorithm within the insulin pump to adjust insulin based on CGM readings. The major similarity between all insulin pumps is that they each automatically adjust basal rates. However, they all have slight differences in how automatic boluses are made, and ultimately patients must still interact with the system to announce when the user is consuming carbohydrates. Right now patients must also wear two separate devices (1 device = continuous glucose monitor vs other device = insulin pump) Diabetes tech companies have been attempting to evolve the hybrid closed loop pump to even more ideal options such as:
    • CamAPS HX FCL system is an insulin pump that works with a CGM to adjust insulin without user interaction when consuming carbohydrates. This is a fully closed loop pump, which would be one step closer to acting like a human pancreas. While it doesn’t look like this algorithm is strong enough yet to bring blood sugars to goal, there were significant improvements in time in range (was able to increase time in range from approximately 32% to 45%)! 
    • PharmSens and SiBionics is ONE device that combines both a CGM and insulin pump in one! Having issues with scar tissue from having to wear so many devices? This may be an exciting option for you!

2. Treatment/Diabetes Management Research

The more we learn the more it is evident that diabetes is a spectrum of autoimmunity, genetics, and insulin resistance. We are also learning more about WHY all of these problems happen. Scientists have established that there are eleven deficits, coined the “egregious eleven” within our body that contribute to insulin resistance.6

While this is encouraging, we still need to learn more – why do some people get diagnosed with type 1 as a child while others are diagnosed much later as adults? The more we learn about the challenges, the more of a chance we have to fix it. After all, the first step of solving any problem is identifying what the problem is.

The pharma industry is going full throttle at finding additional medications/therapies for diabetes management to help support not only your diabetes, but also provide additional benefits like protecting against heart attack/stroke/kidney disease, for example. If one tool can help with multiple areas, why not give yourself extra protection? For example, we know that GLP-1 medications like Ozempic© and Trulicity© can improve health outcomes for folks with T2D by decreasing risk of heart attacks and stroke, but it’s still currently not approved for use in people with T1D. 

  • There are new and existing studies that support the idea that Ozempic© would be helpful for T1Ds for improving time in range and reducing weight (see more here) but why stop there? 
  • What if it was possible to give medications like Ozempic© through a patch instead of an injection or combine medications like Ozempic© with insulin (options such as CagriSema or Icosema)?

As research expands and therapies evolve, the line between managing and mastering diabetes continues to blur, so you will be more equipped to take charge of the battle of diabetes – and win! 

3. Psychosocial/Behavioral Research 

We know diabetes is physical – blood sugar fluctuation can make or break if you are able to participate in an upcoming dance recital or work presentation .  However, the community needs to have a continued conversation about the mental health toll that diabetes takes on those living with the condition. While innovations in tech and meds are great, there is a huge need for more resources and treatment available to make diabetes management less overwhelming, and change stigma with diabetes! 

If only – all those living with diabetes could have a mental health professional and/or diabetes educator on speed dial. However, considering burnout in healthcare is a very real thing at the moment it is not looking like that will be a thing any time soon. However, what will be a thing soon, are smartphone apps that utilize artificial intelligence to analyze your continuous glucose monitor trends and provide personalized dietary, physical activity, and sleep guidance to improve diabetes management. After all, you have gotta get your mind right to get your body right!

Here are a few examples of AI smartphone apps (uses AI to analyze CGM and provide guidance on dietary, sleep, and physical activity recommendations):

4. Public Health/Equity Research

Let’s play a game. You can only pick one answer. Would you rather pay for groceries, rent, or medications? An impossible question to answer, right? Unfortunately, this is reality for many people in the world, even in a country as developed as the United States. 

Minorities, lower income individuals, and those living in rural communities tend to struggle with access to healthcare that meets them where they are. Research on healthy equity aims to understand why communities are facing these additional challenges, and explore innovative solutions that can help increase access to care. 

An emerging area of healthcare would be how telehealth improves care, especially as healthcare moves away from fee-for-service (AKA pays healthcare professionals based on how many patients they see in a day) towards value based care (AKA pays healthcare professionals based on how many patients have an A1c less than 7%). There are studies that analyze medication affordability and negative health outcomes, focus on equal representation in study participants of clinical trials, and telehealth. Diverse representation can make or break what is the standard of care for ALL individuals living with diabetes. 

5. Working towards a “cure”

“I am hopeful there will be a cure for diabetes in our lifetime – give it a few more years.” Now that you’re done rolling your eyes,  I want to tell you that there have been pretty major advancements recently! The latest and greatest news is stem cell transplants. Now what the heck is that? 

Think of a garden. Your garden started out beautiful – lots of flowers and fruits and veggies. However, a family of deer found the garden. They start breaking down your fence to get to the garden and eating everything in sight… They absolutely RUIN the garden. Your challenge would be 1) do you want to try to regrow the garden and 2) when you regrow it how will you prevent the deer from finding it and ruining it again? So the garden=your pancreas and the deer=the autoimmune destruction that happens. Scientists are studying a way to regrow your garen/pancreas and make sure it doesn’t get attacked again. There are two ways they are looking into regrowing your pancreas; 

  1. The first way is through the use of Zimislecel, which focuses on just regrowing your garden (aka pancreas). This treatment consists of transplanting lab-grown beta cells (that produce insulin) in hopes that participants would be able to produce their own insulin, no longer requiring external insulin. This treatment does require immunosuppressants so that the new cells are not rejected by the body. Trials for Zimisclecel are in the early phases, but are showing promising results for moving towards the next phase!
  2. The second way is through use of UP421 which focuses on regrowing the garden (aka pancreas) with adequate protection to hide from the deer so they cannot find the garden (aka the autoimmune destruction). 

There is still a ways to go before FDA approval and insurance coverage is available for these therapies but in the very small trials we have there has shown a significant reduction in insulin use with some participants able to get off of ALL insulin. So fight the urge to roll your eyes next time you hear about a cure and focus on where you can support the research!! 

Conclusion: Why ALL types of research matter

You can make an impact and volunteer in research happening right now. Talk with your provider about how you can stay up to date on opportunities that are available. Research is more than taking a new medication or testing a new device – it even includes sharing your opinion so scientists can better understand what it means to live with diabetes and how it could be improved. These are often paid opportunities!

Next time you are doom scrolling across your socials and you see a post about something new available for diabetes care, reflect to yourself how this research moves the needle towards a future of better diabetes care (or better yet – no more diabetes to care for!)

Keep in mind, resharing the research opportunity spreads awareness, which is just as important as the decision to participate in the research or not. Change starts with one voice, one choice, one person willing to say, “I want better for myself and the future”. So go ahead: be the change you wish to see in the world…and get paid for it while you are at it.

Citations

  1. Eknoyan G, Nagy J. A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease. Adv Chronic Kidney Dis. 2005 Apr;12(2):223-9. doi: 10.1053/j.ackd.2005.01.002. PMID: 15822058.
  2. Eknoyan G. A history of diabetes mellitus — a disease of the kidneys that became a kidney disease. J Nephrol. 2006 May-Jun;19 Suppl 10:S71-4. PMID: 16874717.
  3. Dall’Olio G, Dorizzi RM. Diagnosis of diabetes mellitus at the hospital of Venice in 1863. Clin Chim Acta. 2000 Jul;297(1-2):17-27. doi: 10.1016/s0009-8981(00)00230-8. PMID: 10841905.
  4. Polonsky KS. The past 200 years in diabetes. N Engl J Med. 2012 Oct 4;367(14):1332-40. doi: 10.1056/NEJMra1110560. PMID: 23034021.
  5. Reichman TW, Markmann JF, Odorico J, Witkowski P, Fung JJ, Wijkstrom M, Kandeel F, de Koning EJP, Peters AL, Mathieu C, Kean LS, Bruinsma BG, Wang C, Mascia M, Sanna B, Marigowda G, Pagliuca F, Melton D, Ricordi C, Rickels MR; VX-880-101 FORWARD Study Group. Stem Cell-Derived, Fully Differentiated Islets for Type 1 Diabetes. N Engl J Med. 2025 Sep 4;393(9):858-868. doi: 10.1056/NEJMoa2506549. Epub 2025 Jun 20. PMID: 40544428.
  6. Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR 3rd, Aguilar RB. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema. Diabetes Care. 2016 Feb;39(2):179-86. doi: 10.2337/dc15-1585. PMID: 26798148; PMCID: PMC5317235.